4111 Corneal transplantation causes recurrent herpes simplex in rats

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4111 Corneal transplantation causes recurrent herpes simplex in rats

&gg2g To study HSV reactivation end recurrent disease after comeal transplantation in rats. Methods Female PVG rats were inoculated on the comea with HSV-1 McKrae. At least 4 weeks after inoculation. they received either allogeneic (DA or LEW) or syngeneic corneel grafts end were exemined for stgns of recurrent HSV disease for up lo 30 days. m All allografts wara rejactad. Virus was shed in the...

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Corneal transplantation for herpes simplex keratitis.

We conducted a retrospective study of 107 penetrating keratoplasties in 99 eyes (99 patients) performed from 1970 to 1979 at the Wills Eye Hospital. The follow-up periods ranged from one to 12 years (median, three years). Overall, 86 of the 107 transplants (80%) remained clear and 63 eyes (59%) achieved good to excellent visual acuities (20/60 or better). Preoperative vascularization was not a ...

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Recurrent cutaneous herpes simplex in hairless mice.

Passively immunized hairless mice were inoculated cutaneously with herpes simplex virus. Thirty-nine days later, when the primary cutaneous lesions had completely healed, the mice were treated subcutaneously with prednisone. Within 12 to 30 days after starting prednisone treatment, herpesvirus was recovered by skin swabs from 12 of 71 (17%) of the treated mice. This new model has potential appl...

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Recurrent Herpes Simplex Keratitis in Penetrating Keratoplasty

Purpose and Methods: Penetrating keratoplasty (PK) in herpes simplex keratitis (HSK) is increasingly performed not only for visual purposes but also to remove viral antigen from the cornea and to reestablish the structural integrity of the eyes. With the improvement of medical management and surgical techniques which lead to a higher survival rate of the graft, PK in HSK still carries a high co...

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Recurrent herpes simplex labialis: selected therapeutic options.

Recurrent infection with herpes simplex virus 1 (HSV1), called herpes simplex labialis (HSL), is a global problem for patients with normal immune systems. An effective management program is needed for those with frequent HSL recurrences, particularly if associated morbidity and life-threatening factors are present and the patient's immune status is altered. Over the past 20 years, a variety of ...

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ژورنال

عنوان ژورنال: Vision Research

سال: 1995

ISSN: 0042-6989

DOI: 10.1016/0042-6989(95)90356-9